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Romanian Journal of Biology - Zoology
ROMANIAN ACADEMY |
ELECTRON MICROSCOPIC INVESTIGATIONS OF THE TUMOR-STROMA INTERFACE DURING SKIN BASAL CELL CARCINOMA DEVELOPMENT
ANA-MARIA MOROȘANU*, LEON DĂNĂILĂ**, GABRIEL-VALERIU MIRANCEA***, DANIEL FLORIN JURAVLE****, VLAD DENIS CONSTANTIN***, NICOLAE MIRANCEA*
Abstract:
The aim of this paper is to know subtle infrastructural alterations of cancer cells per se as well as associated tumor stroma of basal cell carcinoma (BCC). From the external part of the tumor mass towards the associated stroma a gradually alteration of histoarchitecture is remarkable. Basement membrane and hemidesmosomes are severely altered or totally abolished. Tumor cells affronted to the stromal microenvironment shed extracellular microvesicles. Because of high fragility of tumor associated microvasculature, extravasated inflammatory cells become intermingled with tumor cells. Inside of tumor mass, particular conduit systems delimited by tumor cells can be detected. A recently described cell phenotype termed telocyte is present inside of peritumoral stroma of all our investigated cases of BCC. These peculiar stromal cells establish both homo- and heterocellular junctions.
Citation:
ANA-MARIA MOROȘANU*, LEON DĂNĂILĂ**, GABRIEL-VALERIU MIRANCEA***, DANIEL FLORIN JURAVLE****, VLAD DENIS CONSTANTIN***, NICOLAE MIRANCEA*, 2022. ELECTRON MICROSCOPIC INVESTIGATIONS OF THE TUMOR-STROMA INTERFACE DURING SKIN BASAL CELL CARCINOMA DEVELOPMENT, Romanian Journal of Biology - Zoology, 67(1-2): 87–106.
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